Endocrine Abstracts

Objective: To evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly.Methods: Ninety-three acromegalic patients (52 male/41 female) were included in this study who were seperated into three groups as normal glucose tolerance (NGT), prediabetes and diabetes mellitus (DM). Insulin resistance (IR) was calculated with homeostasis model assessment (HOMA). HOMA-IR >2.5 or ≤2.5 were defin...

Objective: The aim of the study is to evaluate both the long-term consequences of exposure to dopamine agonists (CAB and BRC) at the beginning and during pregnancy, and the effects of pregnancy on remission.Methods: Thirty-seven prolactinoma patients who developed 58 pregnancies while receiving DAs treatment were included in this retrospective study. Age of gestation; both maximum residual tumor diameter and PRL levels before conception; the course of pr...

Background: Subacute thyroiditis (SAT) is a transient inflammatory, probably viral disease of the thyroid gland. It is clinically characterized by pain, fever, increased erythyrocyte sedimentation rate (ESR) or other markers of inflammation, transient thyrotoxicosis, and has a tendency to recur. In most cases, in addition to the clinical features, scintigraphy and ultrasound may support the diagnosis of SAT. However, in the present case, SAT with an atypical thyroid 99m</...

Introduction and aimGraves’ disease which is the most common cause of hyperthyroidism is an autoimmune disease presenting with goitre, orbitopathy and dermopathy. The disease is caused by stimulant type TSH receptor antibodies (TRAB). TSH receptor (TSHR) has been shown in different tissues other than thyroid. Testis is one of the extrathyroidal tissues with TSHR. The aim of this study was to investigate relationship between TRAB and inhibin-B, whic...

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

Introduction: Dopamine agonists (DAs) consisting of cabergoline (CAB) or bromocriptine is the primary therapy in prolactinomas. DAs are also used in Parkinson’s disease and restless leg syndrome with much higher doses. As a result of reports related to doses in these patients, it is known that long term use of DAs can lead to fibrotic syndromes affecting heart and lung. Cardiac valvulopathies are the most common investigated side effects but there are case reports of ple...

Objective: There is not sufficient data about oxidative stress in euthyroid Hashimoto (EH) and subclinical hypothyroid Hashimoto (SHH) disease. We studied oxidative stress with more oxidative stress tests in EH and SHH patients and assessed whether there is an association betweeen Hashimoto disease and PON1 phenotype.Materials and method: 35 EH and SHH patients and 38 control was included to the study. Comprehensive biochemistry, routine blood analysis, ...

Introduction: Subacute thyroiditis (SAT) is the inflammatory disease of thyroid gland, which commonly affects middle-aged females. SAT is rarely seen in extreme age groups. Herein, we reported an 82-year-old patient presenting recurrent SAT.Case report: An 82-year-old female patient presented fever, neck pain, weakness, and dizziness. She had hypertension and peripheral vascular disease. She had a 2-week of symptom history and admitted to emergency servi...

Graves’ disease (GD) is an autoimmune and polygenic disorder. The genetic loci conferring susceptibility need to be still defined. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene has been reported to be associated with GD in various ethnic groups. The aim of the present study was to determine whether CTLA-4 gene was associated with GD in Turkish population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1 (+49 A/G) and promoter (−318 C/T) reg...

Aims: In this study, we examined the relationships between levels of adipocytokines and traditional and non-traditional cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM).Methods: Serum leptin, resistin, adiponectin, visfatin, high sensitive C-reactive protein (hsCRP), homocystein, asymetric dimethylarginine (ADMA), fasting glucose, insulin, glycated haemoglobin (HbA1C) and full lipid and lipoprotein profile, systolic...